Drosophila SNF2-type ATPase CHD1 catalyzes the assembly and remodeling of nucleosomal arrays in vitro and is involved in H3.3 incorporation in viin vivo during early embryo development.Evidence for a role as transcriptional regulator comes from its colocalization with elongating RNA polymerase II as well as from studies of fly Hsp70 transcription.H
Cumulative evidence supports a role for neutralizing antibodies contributing to spontaneous viral clearance during acute hepatitis C virus (HCV) infection.Information on the timing and specificity of the B cell response associated with clearance is crucial to inform vaccine design.From an individual who cleared three sequential HCV infections with
Prolonging dairy cattle longevity is regarded as one of the options to contribute to a more sustainable milk production.Cattle longevity is a direct result from culling decisions, which is primarily driven by economic considerations.As a consequence, at the herd level, cattle longevity can have effects on the Floor Squeegees efficiency of dairy pro
RationaleThe beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults.To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute 503 injury.This observation has been repeated by multiple groups and in multiple models; however, whether incr